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Senate holds a procedural vote on the Digital Asset Market Clarity Act on Tuesday, a measure requiring 60 votes to advance.
The bill, which spans over 600 pages, seeks to establish the first federal regulation of the U.S. crypto sector after a version cleared the House last year.
To pass, the legislation needs support from all 53 Senate Republicans and at least seven Democrats.
Elizabeth Warren, D-Mass., has criticized the draft, stating it fails to adequately protect investors, the financial system, and national security.
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