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DNA shifts may warn of blood cancer progression a decade before routine tests detect trouble

8/13/2026

A decade is how far ahead genetic changes in blood cells may signal a blood cancer's trajectory, Orlando Health oncologist Abhishek Chilkulwar, M.D.

said, commenting on a Cancer Discovery study that followed 30 myeloproliferative neoplasm patients.

Nine of the 30 eventually developed acute myeloid leukemia; three carried a diagnosis of triple-negative essential thrombocythemia but showed no genetic cancer markers at all.

What the study measured Myeloproliferative neoplasms (MPNs) are a group of blood cancers in which the bone marrow produces too many blood cells. Researchers at the Wellcome Trust Sanger Institute in the U.K.

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